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The SARS-COV-2 Virus: Mutations & Evolution

How is the SARS-COV-2 virus mutating and evolving? Why is one sub-type, A2a becoming more common across COVID-19 infections across the world? What impact does the defining D614G mutation have on the infection? Distinguished genomics researcher Partha P Majumder joins host Pavan Srinath to explain the science, and share his latest research on Episode 136 of  The Pragati Podcast.

The SARS-COV-2 virus started infecting humans in Wuhan in late 2019. How has the virus mutated and evolved so far? With 1-2 mutations occurring per month, researchers are now seeing a clade or a sub-type of the virus: A2a, becoming more common in COVID-19 infections across the world. Partha P Majumder, Nidhan Biswas and their colleagues at the National Institute of Biomedical Genomics have done seminal work on analyzing the ongoing mutations and evolution of the SARS-COV-2 virus.

Dr Partha Pratim Majumder, one of India’s foremost researchers in statistical genomics and human genome variation, joins host Pavan Srinath on Episode 136 of The Pragati Podcast to unpack viral evolution and understand the latest research on how SARS-COV-2 has mutated and evolved till date.

Dr Majumder is the Founder and a Distinguished Professor at the National Institute for Biomedical Genomics (NIBMG) at Kalyani, West Bengal, and is currently the President of the Indian Academy of Sciences. NIBMG Webpage | Google Scholar Profile.

His latest research on SARS-COV-2:

  1. Biswas, N and Majumder, PP. Analysis of RNA Sequences of 3636 SARS-CoV-2 Collected from 55 Countries Reveals Selective Sweep of One Virus Type. Indian Journal of Medical Research. (In Press, April 28, 2020)
  2. Bhattacharya, C. et al. Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of TMPRSS2 and MX1 Genes. (Preprint, May 05, 2020)

This is the 13th podcast episode on various aspects of the COVID-19 pandemic hosted by Pavan Srinath, across The Pragati Podcast, Thale-Harate Kannada Podcast & BIC Talks. You can find links to all of them here.

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